In patients with temporomandibular joint (TMJ) osteoarthritis, autologous platelet-rich plasma (PRP) injection effectively mitigates pain with an improved interincisal opening. Nevertheless, it is associated with greater complications as compared to chitosan injection.

Osteoarthritis of TMJ is a painful deteriorating jaw joint disease. This retrospective cohort study was performed to evaluate the outcome of autologous PRP vs. chitosan injection for TMJ osteoarthritis.

The maximum interincisal opening, degree of pain, and TMJ sounds of 27 patients with TMJ osteoarthritis were noted. These values were compared prior to treatment and at the 3rd and 6th months following the treatment. The data of each group (PRP group and Chitosan group) was analyzed via SPSS 24.0 software. A comparison of imaging changes in the condylar bone was done before and 6 months following the treatment. 

Patients on PRP treatment had better results concerning maximum interincisal opening and pain than the chitosan treatment group. Both groups had relief associated with TMJ sounds. But, the difference didnot display statistical significance. 

PRP treatment displayed improved maximum interincisal opening and pain in TMJ osteoarthritis as compared to chitosan.