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A retrospective analysis was carried out to explore the relation between white matter lesions (WML) and Helicobacter pylori (H. pylori) infection in episodic migraine patients.
In people diagnosed with migraine, H. pylori infection can be deemed as a risk factor in the development of white matter lesions.
A retrospective analysis was carried out to explore the relation between white matter lesions (WML) and Helicobacter pylori (H. pylori) infection in episodic migraine patients.
Overall, 526 people (mean age 45.57 ± 13.46 years) suffering from episodic migraine were enrolled. With brain magnetic resonance imaging (MRI) examinations, the hyperintensity of WML had been formerly assessed in these patients.
Recording of former endoscopic gastric biopsy histopathological assessment and reports on H. pylori findings was done. The demographic properties of patients, like gender, age, and chronic systemic diseases like diabetes mellitus (DM) and hypertension were recorded. Statistical assessment was made.
In 33.8% (n = 178) of H. pylori-infected patients, WML was seen at a 2.5-fold greater occurrence on their brain MRI (odds ratio: 2.562). Contrasted to people without migraine and hypertension, WML was more profound in people with migraine and hypertension. Older age was also related to WML (odds ratio = 1.07). As per the multivariate logistic regression analysis, hypertension + DM, hypertension, H. pylori, and age had remarkable correlations in predicting WML. Compared to other variables, hypertension exhibited a greater odds ratio value.
The presence of H. pylori was associated with a rise in WML development in migraine patients. Hence, H. pylori elimination may aid to lower WML risk in migraine.
BMC Neurology
Relationship between Helicobacter pylori infection and white matter lesions in patients with migraine
Serkan Öcal et al.
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