Association between NAFLD and H. pylori infection: A Meta-analysis

Summaries 3 min 308

Font Size

Created On: 03/05/2023

A meta-analysis aimed to explore the connection between nonalcoholic fatty liver disease (NAFLD) and Helicobacter pylori (H. pylori) infection.

See All

Key take away

Infection with H. pylori is linked with NAFLD development, particularly moderate and severe NAFLD.

Background

A meta-analysis aimed to explore the connection between nonalcoholic fatty liver disease (NAFLD) and Helicobacter pylori (H. pylori) infection.

Method

Cochrane Library, EMBASE, and PubMed databases were explored. Only a random-effects model was employed. The combined estimation of the data adjusted for confounders were derived as adjusted ORs (aORs) and hazard ratios (aHRs) with 95% confidence intervals (CIs) while for the combined estimations of the raw data, odds ratios (ORs) and risk ratios (RRs) along with 95% CIs were estimated.

Result

Overall, 34 studies with 218573 individuals were incorporated. Unadjusted data from twenty-six cross-sectional studies and three case-control studies revealed a substantial association between H. pylori disease and the occurrence of NAFLD (OR = 1.26). Adjusted data from fifteen cross-sectional studies and one case-control research revealed a profound correlation between H. pylori disease and the occurrence of NAFLD (aOR = 1.25).

Subjects with moderate (OR = 1.67) and severe (OR = 1.71) NAFLD, but not those with mild NAFLD (OR = 1.14) showed a substantially greater percentage of H. pylori infection as contrasted with control participants without NAFLD. Based on data from 3 cohort studies that had been statistically adjusted, the link between H. pylori infection and the development of NAFLD was clinically meaningful (aHR = 1.18), but not from data that had been unadjusted (RR = 1.41).

Conclusion

Therefore, there is a positive correlation between NAFLD (moderate and severe) and H. pylori infection. It is pivotal to further explore the effect of eliminating H. pylori on NAFLD prevention.