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This prospective cross-sectional study investigated the effectiveness of vitamin D supplementation as a standard dose for attaining acceptable levels in exclusively breast-fed newborns with varying cord 25(OH)D levels along with associated neonatal morbidities.
Implementing personalized dosing strategies may help augment vitamin D levels in at-risk infants, thus enhancing overall neonatal health outcomes.
This prospective cross-sectional study investigated the effectiveness of vitamin D supplementation as a standard dose for attaining acceptable levels in exclusively breast-fed newborns with varying cord 25(OH)D levels along with associated neonatal morbidities.
Term infants were categorized into three groups based on umbilical cord 25(OH)D levels:
A comparison of Cord and 1st-month 25(OH)D levels, following vitamin D (standard dose) prophylaxis, neonatal outcomes, and body measurements (height, weight, etc.) was done.
Overall, 86 infants were considered. Of the three, Group 1 exhibited considerably lower 25(OH)D levels in 1st month (p < 0.001). A notable positive correlation was observed in 25(OH)D levels between the cord and 1st month (r = 0.78, p < 0.001).
Despite similar maternal age, Group 1 mothers had higher parity numbers and lower vitamin D usage during pregnancy. Examination of neonatal outcomes indicated increased frequency of respiratory distress, transient rapid breathing, early-onset sepsis, and prolonged hospitalization in the first month of newborns of this group (p < 0.05).
Infants with low cord vitamin D levels exhibited reduced 25(OH)D values in the 1st month of life and were linked with higher risks of morbidities in newborns.
MDPI-Children
A Prospective Cross-Sectional Study on the Vitamin D Status of Neonates and the Impact of Neonates’ Standard Vitamin D Supplementation on Neonatal Morbidities
Ezgi Yangin Ergon et al.
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