Categories
Change Password!
Reset Password!
Rheumatoid arthritis (RA) is an autoimmune problem recognised by joint and bone disruption, but other organ systems can also be affected.
Rheumatoid arthritis (RA) is an inflammatory
disorder characterized by bone and joint destruction. It has been reported in
previous studies that exhaled nitric oxide (NO) is a non-invasive marker of
airway inflammation and has been found higher in many diseases. In the present
study author compare the NO parameters between subjects with RA to healthy
control subjects, and showed significant differences between subjects with RA and
matched healthy control subjects regarding the exhaled NO parameters.
Rheumatoid arthritis (RA) is an autoimmune problem
recognised by joint and bone disruption, but other organ systems can also be
affected. According to the recent studies, RA may also affect the lungs.
Exhaled nitric oxide (FENO) is considered as one of the markers of
inflammation. The study compares the NO parameters within RA and healthy
control subjects and assess whether the NO parameters associated with the
functioning of lungs and disease activity among RA patients.
Individuals were selected at the time of their routine
outpatient visits to the rheumatology department. An algorithmic estimation of
nitric oxide (NO) parameters (tissue concentration of NO in the airway wall
(CawNO), alveolar NO concentration (CANO), and airway compartment diffusing
capacity of NO (DawNO) were conducted. Controls involved the healthy
participants who matched by gender, height and age. Median was used to
represent the data. Group comparison was done by applying the Wilcoxon Matched
Pairs test and comparisons between any two groups, and for pairwise
comparisons, the Mann-Whitney U test was applied. Further, the Spearman rank
order correlation was used to test the associations.
As compared to healthy subjects, RA patients exhibited
significantly lowered CANO and CawNO with higher DawNO.
A significant difference was between healthy and RA
subjects about exhaled NO parameters. It is uncertain if this can be defined by
the pathogenesis of RA, outcomes of long-term disease, and/or due to drug
therapy.
Nitric Oxide
Altered levels of exhaled nitric oxide in rheumatoid arthritis
AlexandraThornadtsson et al.
Comments (0)