Nebulization with alkaline hypertonic ibuprofenate triggers an expeditious rise in platelets circulating in SARS-CoV-2 patients but not in healthy volunteers.

This study determined alterations in platelets in coronavirus-positive people who received conventional therapy enoxaparin and dexamethasone vs. people treated with the combination of conventional therapy and nebulization with alkaline hypertonic ibuprofenate. 

In this study, the change in the levels of circulating platelets via alkaline hypertonic ibuprofenate was assessed. To check if this action was associated with platelets from coronavirus-positive subjects or also for healthy subjects, 2 controls were incorporated: 1 of them with ten healthy volunteers and another one with coronavirus-positive subjects hospitalized and treated only with dexamethasone and enoxaparin.

Table 1 shows a rise in the circulating platelets following twenty-four hours of nebulization with alkaline hypertonic ibuprofenate, in people having platelets content below 200,000 by microliter and above 200,000 by microliter. 

Both males and females showed a comparable rise in the levels of circulating platelets via alkaline hypertonic ibuprofenate. It was found that in healthy people, the number of circulating platelets remains unaltered even after seven days of therapy with alkaline hypertonic ibuprofenate. In coronavirus-positive people treated only with dexamethasone and enoxaparin for four days, only a 16% increase in platelets was noted. 

Alkaline hypertonic ibuprofenate is associated with an escalation in the levels of circulating platelets in COVID-19 people.