The poor response to treatment linked with alcohol misuse and obesity reported in people with moderate-to-severe psoriasis calls for lifestyle behaviour change interventions and support as a part of routine clinical care.

This prospective cohort study was carried out to determine if alcohol misuse is linked with poor response to psoriasis therapy.

Overall, 266 participants were incorporated (biologic cohort [134 people]; conventional systemic cohort [132 people]) in this multicentre study. With the aid of the Psoriasis Area and Severity Index (PASI), the response to systemic therapies was evaluated.

For screening  alcohol misuse, the CAGE (Cut down, Annoyed, Guilty, Eye opener) questionnaire was utilized. For examining factors linked with alteration in PASI between baseline and follow-up, a multivariable factional polynomial linear regression model was utilized.

For the entire cohort, the median (interquartile range) PASI improved during follow-up when compared to the baseline.

A higher CAGE score, obesity, and receiving a conventional systemic rather than a biologic therapy were substantially linked with poor response to therapy. On the other hand, a higher baseline PASI was linked with a better response to therapy.

Targeting interventions for preventing, detecting and managing alcohol misuse in psoriasis people is required for decreasing adverse health consequences and for improving therapy response.