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A retrospective propensity score matching analysis was carried out to determine the safety and efficacy of HDDT 10-day vs 14-day and explore the factors that may influence the helicobacter pylori (H. pylori) elimination rates.
Compared to a 10-day high-dose dual
therapy (HDDT), the 14-day HDDT affords a greater H. pylori elimination rate.
A retrospective propensity score
matching analysis was carried out to determine the safety and efficacy of HDDT
10-day vs 14-day and explore the factors that may influence the helicobacter
pylori (H. pylori) elimination rates.
In this analysis ascertaining if
HDDT with distinct regimens leads to different elimination rates, the
participants were allocated to either a 10-day HDDT group or a 14-day HDDT
group (20 mg esomeprazole and 750 mg amoxicillin, given 4 times daily).
Comparison of the elimination rates, CYP2C19 gene polymorphisms, patient compliance,
antibiotic resistance rates, and adverse events were done.
The elimination rate as per intention to treat (ITT) and per-protocol (PP) analysis, and drug-related adverse events is shown in Table 1:
No profound differences were
witnessed between the compliance rates of the groups. The CYP2C19 gene polymorphism
did not influence the elimination rates of the groups.
The 14-day HDDT can be preferred
over the 10-day HDDT in patients with H. pylori infection.
Helicobacter
10-Day and 14-day high-dose dual therapy for the treatment of Helicobacter pylori: A propensity score matching analysis
Pei-Ying Zou et al.
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