Premenopausal women with migraine have more intense endometriosis (EM) symptoms at lower endometriosis stages, a study published in the “Journal of Women’s Health” outlined. This inconsistency intensely designates pain sensitizations and a reduced pain threshold in women suffering from endometriosis-migraine. Maria Susanne Neumeier et al. performed this study to examine the differences in clinical manifestations, severity, and symptoms of EM features in females with EM and migraines (EM-MG) and women with only EM (EM-O).

In this cross-sectional observational study, premenopausal women who underwent endometriosis surgery were considered (total women who participated= 344). The data about infiltration depth and localization of EM was accessible. The study researchers interviewed these women with the help of a planned questionnaire about clinical features, symptoms and medication history. The categorical variables were stated as frequencies while the continuous variables were stated as means with standard deviations.

The Fisher's exact test, chi-square test, independent sample t-test, and Wilcoxon-Mann-Whitney test were used to distinguish the subgroups (EM-MG versus EM-O) with a significance level of 0.05. EM-O had 250 participants and EM-MG had 94 participants. The women in the EM-MG exhibited less severe revised American Society of Reproductive Medicine scores, more deliveries, more and elevated scores of dysmenorrhea at first menstrual cycle, lengthy heavy menstrual bleeding, more and sustained pain during menstrual bleeding, and more trouble pooping than EM-O.