The sedative outcomes of Pregabalin during the perioperative period have not been identified sufficiently. A study was therefore conducted to estimate the sedative effects of premedication with pregabalin on intravenous sedation (IVS) using propofol.

During the study, pregabalin effects upon post-anesthetic complications, circulation, and respiration were also evaluated. The study was conducted among 10 healthy young volunteers. These volunteers went through IVS using propofol, three times for 1 hour. The first time they went through IVS with no pregabalin, second time with 100 mg pregabalin and third time with 200 mg pregabalin. Further, on the basis of bispectral index (BIS) value, the propofol's target blood concentration (CT) was evaluated at each sedation level. Moreover, at each propofol CT, Ramsay's sedation score (RSS) was also assessed. Respiration and circulation were also determined during studies.

Finally, propofol CT was found to be decreased in both premedicated groups at BIS values of 60 and 70 and in pregabalin 200 mg group at a BIS value of 80. Propofol CT in the pregabalin 100 mg group was reduced at RSS 4-6 and in the pregabalin 200 mg group at RSS 3–6.