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Vitamin D supplements are
beneficial and can improve symptomatic and functional outcomes in individuals
with knee osteoarthritis.
In people suffering from knee osteoarthritis, supplementation of vitamin D is associated with improvement in WOMAC pain and functional improvement, as deduced from a systematic review and meta-analysis conducted by Zi-Xia Zhao et al. Researchers aimed to yield evidence on the efficacy of vitamin D supplementation for clinical prevention and management of knee osteoarthritis.
For finding relevant studies, databases like SinoMed, Web of Science, China National Knowledge Infrastructure, PubMed, Wanfang, China Biological Medicine Database, and Embase were searched. For the meta-analysis, RevMan5.3 software was utilized. The findings of the study were expressed as standardized mean difference (SMD) with 95% confidence interval (CI) or weighted mean difference with 95% CI.
The study included 6 randomized controlled trials and 1599 participants having knee osteoarthritis. Supplementation with vitamin D was found to be statistically significant for Western Ontario and McMaster Universities Arthritis Index (WOMAC) score (SMD = - 0.67) in knee osteoarthritis people, including stiffness score (SMD = - 0.13), WOMAC pain score (SMD = - 0.32), and function score (SMD = - 0.34). In the subgroup assessment, vitamin D supplementation less than 2000 international units (IU) was statistically significant for the decline in stiffness score (SMD = - 0.22).
Supplementation with vitamin D is
associated with a reduction in synovial fluid volume advancement in people
having knee osteoarthritis (SMD = - 0.20). Regarding improvement in bone marrow
lesions (SMD = 0.03), tibia cartilage volume (SMD = 0.12), and joint space
width (SMD = - 0.10), no statistical significance was noted. However, there is
a paucity of strong evidence that vitamin D supplements can aid in the
prevention of structural advancement in knee osteoarthritis.
Aging clinical and experimental research
Does vitamin D improve symptomatic and structural outcomes in knee osteoarthritis? A systematic review and meta-analysis
Zi-Xia Zhao et al.
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