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Vitamin D supplementation helps ease endometriosis symptoms such as dysmenorrhea, dyspareunia, and dyschezia, but its direct effect on pregnancy rates in affected women is yet to be explored.
Vitamin D is known for its immunomodulatory and anti-inflammatory properties, as well as its role in hormonal regulation which is considered pivotal in managing various aspects of endometriosis. Hence, researchers performed a study to examine the effects of vitamin D on conception rates and clinical signs in females suffering from endometriosis.
A thorough search of electronic databases, including PubMed, Cochrane Library, EMBASE, Ovid MEDLINE, and CINAHL was conducted up to July 20, 2023. ReVMan software was used in the meta-analysis to compute the mean differences, or pooled effect estimates, for continuous data and the associated 95% confidence intervals (CI). Overall, three randomized controlled trials with 167 participants were included.
As found, vitamin D supplementation effectively alleviated dysmenorrhea associated with endometriosis, (mean difference −1.41, 95% CI −2.61 to −0.22, P = 0.02). But, the effect on dyspareunia was ambiguous, with an insignificant mean difference of −0.2 (95% CI −1.62 to 1.22, P = 0.78). Conversely, vitamin D use was linked with a substantial decrease in dyschezia (mean difference −1.10, 95% CI −2.22 to 0.02, P = 0.05).
No significant impact of vitamin D was observed on endometriosis-related chronic pelvic pain. While the antioxidant vitamin D helps relieve endometriosis symptoms, its direct impact on pregnancy rates remains unexplored. Vitamin D therapy can be a viable option for tackling endometriosis symptoms, either alone or with other treatments. The improvement in symptoms may indirectly boost fertility and pregnancy outcomes.
Annals of Medicine and Surgery
The impact of vitamin D treatment on pregnancy rate among endometriosis patients: a systematic review and meta-analysis
Oadi N. Shrateh et al.
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