A study published in the "Journal of Clinical Medicine" depicted that vitamin D supplementation is safe, well-tolerated, and boosts quality of life and psychological well-being in fibromyalgia patients. Given the unmet clinical requirement for efficient therapeutic alternatives, Chia-Chun Yang et al. sought to evaluate the effect of vitamin D on quality of life, psychological endpoints, and pain scores in fibromyalgia.

A meta-analysis of trials contrasting vitamin D to placebo and prospective studies investigating alterations prior to and after vitamin D supplementation was carried out. Databases were explored for pertinent publications. According to the results of 8 trials involving 694 volunteers, vitamin D supplementation substantially improved physical function [standard mean differences (SMD) = 0.44], emotional health-related role limitations (SMD = 0.57), social function (SMD = 0.50), and general health (SMD = 0.36).

Enhancement on Visual Analogue Scale (VAS) (SMD = -0.15) and Beck's Depression Inventory (BDI) scores (SMD = -0.456) were not seen. However, there was an improvement in the Fibromyalgia Impact Questionnaire (FIQ) scores (SMD = -0.414). Therefore, supplementing with vitamin D may be an alternative to boost fibromyalgia sufferers' quality of life and psychosocial outcomes.