In a study published in the journal 'Arthroscopy, Sports Medicine, and Rehabilitation', a startling 3.8% of a total 236 patients who underwent total shoulder arthroplasty developed Prineo adhesive-associated allergic contact dermatitis (ACD). Desiree E. Ojo et al. investigated the occurrence and risk factors associated with ACD in patients who underwent total shoulder arthroplasty and received Prineo, a skin adhesive closure system in their recent retrospective case-control study.

Prineo was frequently employed alongside wound closure, and the study explored established ACD risk factors (like a history of contact dermatitis and smoking) using Fisher exact and Wilcoxon rank sum tests to determine their connection with the development of Prineo-related ACD. Out of the 236 patients with Prineo after shoulder arthroplasty between June 2019 and July 2021, nine cases of Prineo-ACD were recorded, and their complications were recognized and successfully managed, with no adverse impact on the shoulder arthroplasty outcome.

One of the most concerning discoveries was the strong association between a history of adhesive or contact allergy and the development of Prineo-associated ACD. In fact, in a multivariate model, the odds of experiencing Prineo-associated ACD were a staggering 38.5 times higher for individuals with adhesive or contact allergies compared to those without such allergies. Thus, a significant risk factor for the development of Prineo-ACD was a clinical history of adhesive allergy or contact dermatitis, supported by statistical significance.

These findings emphasize the importance of thorough preoperative assessments and awareness of patients' allergic histories, especially in cases where skin adhesives are used.