A study depicted that ultrasound-guided prolotherapy (regenerative injection therapy) with 25% dextrose is beneficial for treating symptomatic temporomandibular joint dysfunction, as evidenced by safety, pain alleviation, therapy advantages, simplicity, patients' acceptance of the injection technique, and lack of vital adverse effects.

A trial was carried out to determine the merits of ultrasound-guided prolotherapy with 25% dextrose in individuals diagnosed with temporomandibular joint disorder. The study cohort included 15 patients suffering from temporomandibular joint dysfunction. The included participants were given two sessions of injections with 3 ml of proliferant solution (2 ml of 25 % dextrose and 2 % lignocaine with 1:2,00,000 adrenaline) 1 month apart. The follow-up was carried out for one, three, and six months.

The subjects were assessed for the following parameters: (i) Frequency of dislocation or subluxation, (ii) pain, (iii) clicking sound, (iv) deviation of the mouth, and (v) maximum mouth opening both pre and post-surgery. Utilizing the Wilcoxon matched-pairs test and dependent t-test, the scores were recorded and assessed.

Injections of dextrose solution led to substantial improvement in temporomandibular joint pain, as shown in the following table and figure:

Improvements in mouth opening, deviation of mouth, clicking sound, and the number of locking episodes were also noted after the two sessions of dextrose injections. Thus, ultrasound-guided dextrose prolotherapy yields promising results for temporomandibular joint dysfunction.