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Patients with diabetes has
significantly higher BMD, therefore
more vulnerable at developing fragility fractures.
According to the reports of CaMos, a prospective cohort study, people with type 2 diabetes are frailer as compared to people without diabetes and are more prone to fragility fractures.
The survey involved two-third of women and one-third of men. The first incident clinical fragility fracture was considered as the primary outcome and time to clinical spine fracture, and hip fracture was considered as the secondary outcome. Deficit-accumulation frailty index (FI) was applied to measure frailty status. The interaction between frailty and diabetes was evaluated using the Cox model.
As compared to the controls, diabetic patients showed higher FI and bone mineral density. The association between the risk of incident fragility fractures and FI was significantly high. The interaction was also found to be statistically meaningful. The hazard ratio for the per-0.1 increase in the FI was also higher in diabetic patients. Further, concerning the risk of hip and clinical spine fractures, no evidence of interaction was found between frailty and diabetes.
The authors stated, '' Diabetes
can be a risk factor for fragility fractures, therefore it should be considered
while identifying risk factors among frail patients.''
Diabetes Care
Frailty and Risk of Fractures in Patients With Type 2 Diabetes.
Guowei Li et al.
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