Pregabalin for functional dyspepsia :- Medznat
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Trial reveals significant benefits of pregabalin to treat functional dyspepsia

Trial reveals significant benefits of pregabalin to treat functional dyspepsia Trial reveals significant benefits of pregabalin to treat functional dyspepsia
Trial reveals significant benefits of pregabalin to treat functional dyspepsia Trial reveals significant benefits of pregabalin to treat functional dyspepsia

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Pregabalin considerably alleviated dyspeptic symptoms, particularly in people having predominant epigastric pain syndrome.

As per the outcomes of a randomized clinical trial, pregabalin displayed remarkable benefits in terms of response rate when evaluated by self-reporting of adequate relief, the dyspeptic symptom score (Global Overall Symptom scale), and quality of life (the short-form Nepean Dyspepsia Index scores) in patients with functional dyspepsia.

Researchers undertook this prospective, placebo-controlled, single-centre, double-blind study for determining pregabalin's efficacy and safety profile to treat functional dyspepsia. Participants diagnosed with functional dyspepsia  (age 18-70 years) and who did not respond well to proton pump inhibitors (n=72) were randomized to either pregabalin (75 mg daily) group (n=34) or placebo group (n=38) for eight weeks. A satisfactory relief response rate was the major endpoint, while improvement in pain scores, safety profile, and quality of life were the secondary endpoints.

Table 1 shows self-reported adequate relief rates and decrease in global symptoms in the study groups at weeks 4 and 8.


An improvement in overall quality of life was noted with pregabalin therapy. Dizziness was the most commonly reported adverse event with pregabalin therapy, occurring in about 51.6% of participants. However, it appeared to be well-tolerated following 1st week of therapy. Thus, pregabalin is beneficial to alleviate functional dyspepsia.

Source:

Alimentary Pharmacology & Therapeutics

Article:

Randomised clinical trial: the effects of pregabalin vs placebo on functional dyspepsia

Authors:

Isariyaphong Kotikula et al.

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