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Tree SLIT-tablet markedly improves symptoms in children with allergic rhinitis and conjunctivitis during birch and oak pollen seasons, with a favorable safety profile.
Oak pollen, part of the birch homologous group, is a major cause of allergic rhinitis and/or conjunctivitis (AR/C). Hence, a study issued in “Annals of Allergy, Asthma & Immunology” focused on the use of the tree sublingual immunotherapy (SLIT)-tablet, assessing its ability to improve symptoms of AR/C in children aged 5-17 during pollen seasons. In this phase 3 trial, 952 children with moderate-to-severe tree AR/C were randomly assigned to receive either a daily tree SLIT-tablet or placebo for up to 12 months.
Participants had access to symptom-relieving medications throughout the trial. Estimation of average total combined score (TCS) was the key outcome ascertained. This included the rhinoconjunctivitis daily symptom score (DSS) and daily medication score (DMS) during birch pollen season (BPS). The secondary endpoint was the average TCS during oak pollen season (OPS). The tree SLIT-tablet markedly improved TCS when compared to placebo during both BPS and OPS (Table 1):
During OPS, the DSS improved by 17.8% and the DMS improved by 39.9%. The treatment was generally well-tolerated, with over 99% of adverse events being mild-to-moderate and primarily localized at the application site. Only 2.7% of participants discontinued the SLIT-tablet due to side effects. No cases of eosinophilic esophagitis were reported. However, 1 subject experienced a mild anaphylactic reaction, which was treated promptly with epinephrine and resolved within 2 hours.
This study underscores the outstanding benefits of tree SLIT-tablets in alleviating symptoms and reducing medication reliance in children during pollen seasons. With a favorable safety profile, this innovative therapy represents a transformative approach for tackling AR/C triggered by oak pollen.
Annals of Allergy, Asthma & Immunology
Efficacy with tree sublingual immunotherapy tablet during oak pollen season in children with allergic rhinitis/rhinoconjunctivitis
H. Nolte et al.
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