According to the findings of a clinical trial published in "Anesthesiology and Pain Medicine", topically administered Ketorolac and Marcaine exhibited better efficacy than Marcaine used alone for reducing pain in individuals undergoing hemorrhoidectomy. In this study, the effectiveness of topical Ketorolac was assessed for post-hemorrhoidectomy pain management. The study enrolled 84 people scheduled for hemorrhoidectomy (grade-II hemorrhoids).

Convenience sampling was utilized to choose the participants (46.4% females, 53.6% male), who were then segregated into three groups of 28 at random:  (1) Intramuscular (4 mL 0.5% Marcaine at the surgical site + 1 mL Ketorolac intramuscularly), (2) Topical (4 mL 0.5% Marcaine + 1 mL Ketorolac at the site of surgery), and (3) Control (4 mL 0.5% Marcaine at the surgical site).

The Numerical Pain Rating Scale was used to gauge how much pain patients were experiencing 1, 6, and 24 hours following surgery. With the aid of two-way repeated measures analysis of variance (ANOVA), analysis of data was done. In all four phases of the pain assessment, the topical group's mean pain intensity was considerably lower than that of the intramuscular and control groups (Figure 1).

Due to severe pain, some individuals received pethidine treatment. But, in all three groups, the average level of pain diminished over time. Hence, Ketorolac + Marcaine is beneficial to relieve pain in people undergoing hemorrhoidectomy.