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Addressing thyroid hormone resistance in PCOS patients improves symptoms, menstrual regularity, ovulation, fertility, and reduce insulin resistance and metabolic abnormalities.
Thyroid hormone sensitivity may be closely related to a higher risk of polycystic ovary syndrome (PCOS), illustrated a research by Qian Wang et al. issued in ‘BMC endocrine disorders’.
The study, which involved 415 females (aged 18 to 40 years) diagnosed with PCOS and 137 without PCOS as controls, employed advanced methodologies to assess thyroid hormone sensitivity indices. These indices, including the Thyroid-stimulating Hormone Index (TSHI), Thyrotroph Thyroxine Resistance Index (TT4RI), Thyroid Feedback Quantile-based Index (TFQI), and Free Triiodothyronine to Free thyroxine levels (FT3/FT4), were important in estimating the correlation between thyroid function and PCOS risk.
As found, PCOS-afflicted females exhibited elevated levels of TFQI, TSHI, TT4RI, and FT3/FT4 versus the control group. Notably, after adjusting for various factors, noteworthy relations emerged between certain thyroid sensitivity indices and PCOS risk. For instance, higher quartiles of TFQI and TSHI were linked to substantially increased odds ratios for PCOS development, on the other hand, TT4RI presented a protective effect against the syndrome. There was no striking correlation between thyroid-related measures and metabolic parameters among females with PCOS, challenging earlier assumptions about their interconnectedness.
Therefore, there exists an intricate tie between thyroid sensitivity and PCOS, emphasizing the need for further research to validate and explore mechanisms, promising better interventions for at-risk individuals.
BMC endocrine disorders
Correlation between thyroid hormone sensitivity and the risk of polycystic ovary syndrome
Qian Wang et al.
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