According to a recently published double-blind, parallel study in 'Cephalalgia', the evidence backing the advantages of Coenzyme Q10 and L-carnitine supplements on serum levels of lactate and migraine symptoms were obtained. Parisa Hajihashemi and colleagues aimed to determine the effects of combined supplementation of Coenzyme Q10 with L-carnitine on mitochondrial metabolic disorders marker and migraine symptoms among the patients suffering from a migraine. The participants of the study included 56 men and women, aged 20–40 years with a migraine headache. For 8 weeks, the subjects were randomly assigned to receive either 30 mg/day Coenzyme Q10 and 500 mg/day L-carnitine at the same time and/or placebo tablets. The primary outcomes comprised of headache attacks measured at the baseline and at the end of the study. Secondary outcomes were the duration of headache attacks, frequency, serum levels of lactate and the headache diary results (HDR). After 8 weeks, there was a notable reduction in the severity, duration, serum levels of lactate frequency and HDR.

There is a need for future cross-over trial studies confirm these findings, mentioned the study authors.