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Pregabalin provides
better tolerability as compared to gabapentin. Moreover, it offers less pill
burden as compared to gabapentin.
A recent study demonstrated that there is no major variation in pain reduction with gabapentin as compared to pregabalin. However, the incidence of dose discontinuation due to adverse effects was considerably high in the gabapentin group.
This study was performed to compare the reduction in pain and other related effects among patients who were prescribed with either pregabalin or gabapentin. There were 222 patients in the gabapentin group, and 30 patients in the pregabalin group.
The primary result was the considerable improvement in the pain within the six months of treatment with pregabalin or gabapentin. The secondary results include the incidence of reduction and then discontinuation of gabapentinoid dose due to adverse effects. There was no considerable variation in the primary results among the two groups.
Table 1: Baseline sample characteristics
Table 2: Endpoint analysis
When
using gabapentin or pregabalin in palliative care patients, there may be no
difference in pain minimization. Even if both gabapentin
and pregabalin are believed to be the first-line treatment choice for different
neuropathic pain conditions, but pregabalin affords improved tolerability and a
more attractive pill burden. However, there is a requisition of larger
prospective studies to understand more differences between using these drugs in
palliative care.
Journal of Pain & Palliative Care Pharmacotherapy
Comparing Effectiveness of Gabapentin and Pregabalin in Treatment of Neuropathic Pain a Retrospective Cohort of Palliative Care Outpatients
Lisa Dragic et al.
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