Study reveals the effect of Isotretinoin on menstrual cycle

Novel findings from a recent prospective observational study shed light on the impact of oral intake of Isotretinoin on menstrual cycles among acne patients with previously regular periods. This study involving 58,599 female patients aged 14 to 36 using Isotretinoin for acne, found that 37.1% experienced changes in their menstrual cycles. Notably, 89.2% of those affected returned to regular menstrual patterns within 2 months after the treatment.

The study by Diala Alshiyab et al. sought to evaluate associations between Isotretinoin use and menstrual irregularities and documented various changes including amenorrhea, oligomenorrhea, and menorrhagia among participants. Statistical analysis revealed significant correlations between menstrual irregularities and both treatment duration and total accumulative dose of Isotretinoin. Specifically, longer treatment durations and higher cumulative doses were connected to increased odds of experiencing menstrual changes.

Furthermore, a family history of polycystic ovary syndrome (PCOS) emerged as a noteworthy predictor for menstrual irregularities during Isotretinoin therapy.