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Acute COVID infection is related to
a raised bacterial pathogens abundance, including Pseudomonas aeruginosa
in nasal cavity.
A cross-sectional study published in Cell Reports revealed that the inflammatory response elicited by SARS-CoV-2 infection is linked with a greater abundance of bacterial pathogens in the nose that might contribute to the elevated occurrence of secondary bacterial infections. Nicholas S Rhoades et al. undertook this study to examine the association between acute SARS-CoV-2 infection, nasal microbiome, and local host transcriptional response.
Nasal swabs were gathered from 68 coronavirus positive patients (CoV+), 45 coronavirus negative medical care workers, and 21 coronavirus negative patients (CoV-). The nasal microbiome of CoV+ people at the time of diagnosis was found to be unique in comparison with CoV- outpatients and CoV- medical carecare workers (n = 45). This distinct shift is characterized by a raised abundance of bacterial pathogens that is also positively related to SARS-CoV-2 RNA load.
Furthermore, a strong host
transcriptional response was noted in the nasal epithelia of CoV+
people, suggestive of an antiviral innate immune response and neuronal
impairment.
Cell Reports
Acute SARS-CoV-2 infection is associated with an increased abundance of bacterial pathogens, including Pseudomonas aeruginosa in the nose
Nicholas S Rhoades et al.
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