A systematic review and meta-analysis revealed that the use of oral Vitamin E supplements can promote the growth of the endometrial lining in women of reproductive age, particularly benefiting those with thin endometrium conditions. Jia-Hui Wu et al. conducted a study to explore how Vitamin E supplementation influences endometrial thickness and pregnancy outcomes among women facing infertility.

Two researchers conducted a thorough literature screening and extracted data from publications in the Cochrane Library, PubMed, and Embase databases. Seven clinical trials involving a total of 652 participants were included based on specific criteria: (1) original studies, (2) full-text availability in English, (3) intervention involving Vitamin E in the treatment group, (4) measurement of changes in endometrial thickness before and after intervention, and (5) reporting of pregnancy outcomes. Utilizing Revman 5.3 software, statistical analysis was done.

The study revealed that the mean endometrial thickness was greater in the Vitamin E treatment group contrasted to the control group, with a standardized mean difference of 0.57. Subgroup analysis indicated no profound difference in endometrial thickness between those who received 400 IU (267 mg) of Vitamin E daily and those who received 100 mg per day.

Furthermore, there was no significant distinction in ongoing pregnancy rates between individuals who took Vitamin E and those who did not, with an odds ratio of 1.08. Thus, Vitamin E use is beneficial to increase the thickness of the endometrial lining in females of reproductive age. Moreover, there is insufficient evidence to support the idea that taking oral Vitamin E supplements provides benefits for pregnancy outcomes.