A study published in The International Journal of General Medicine stated that although there have been reports of cardiovascular side effects with the use of SARS-CoV-2 vaccines, but the causality is yet to be validated. This is because such cardiovascular adverse events are also usually prevalent in the general public even without the intervention.

This study based on WHO Database (VigiBase) emphasizes on cardiovascular adverse events after COVID-19 vaccination and aimed to examine adverse events associated with the administered vaccine. The cardiovascular adverse events were extracted for three system organ classes [SOCs]) - vascular disorders, investigations, and cardiac disorders. The descriptive statistics were stated in the form of frequency and percentage. The disproportionality analysis was carried out.

Considering the cardiovascular system, about 4863 noxious events were reported from Moderna, 1222 AstraZeneca, BNT162b2 Pfizer, and other SARS-CoV-2 vaccines. The commonly noted adverse events reported with the vaccines are shown in Table 1:

On the basis of disproportionality analysis, cardiac arrest, circulatory collapse, and acute myocardial infarction were related to the vaccines in the age group >75 years. Severe hypertension, palpitations, supraventricular tachycardia, hypertension, and sinus tachycardia were linked across all the age groups and either gender.

Abnormality in electrocardiogram findings, and a rise in the levels of troponin, D dimer, and C-reactive protein were witnessed in the specific age groups or gender or all the participants. Thus, people should be given COVID-19 vaccines, with sustained monitoring of adverse events.