A retrospective study published in "Northwestern Medical Journal" depicted that knee osteoarthritis can be effectively treated with both Ozone and Hyaluronic acid injections. However, intraarticular Hyaluronic acid injections had a more significant and long-lasting impact on function and pain than Ozone injections did on knee osteoarthritis. Researchers aimed to determine the efficacy of Hyaluronic acid and Ozone injections on functional limitations and pain in knee osteoarthritis patients.

Overall, 108 subjects (84 women and 24 men, 40 to 75 years of age) visited outpatient clinics with knee pain lasting longer than three months. Ozone injections were given once a week in 3 doses, and Hyaluronic acid injections were given as a single dosage. Before therapy, one and three months following treatment, Western Ontario and McMaster Universities Arthritis Index (WOMAC) and Visual Analog Scale (VAS) scores were noted.

In total, 76 people were incorporated into the trial. Subjects were randomly assigned to Ozone (n=37) and Hyaluronic Acid (n=39) groups. At all phases, there was no discernible difference between groups in terms of VAS, WOMAC-pain, or WOMAC-total. Between 1st month and 3rd month follow-ups, there were profound differences in the WOMAC stiffness score.

Additionally, the inter-group analysis revealed a substantial alteration in WOMAC-function scores between the pre-therapy and 1st month follow-ups, and the pre-therapy and 3rd month follow-ups. Thus, knee osteoarthritis can be successfully treated with both Ozone and Hyaluronic acid injections. Intraarticular Hyaluronic acid injection, as compared to Ozone injection, had a more enduring impact on pain and function.