A cross-sectional study indicated that the majority of hospitalized patients were given proton pump inhibitors (PPIs) for the suitable indication and at the right dosage, with a high prevalence of  inappropriate intravenous (IV) PPIs,  raising medical care costs and also demonstrated  the  importance of adequately ordering IV medications.

In terms of indication, dosage, frequency, and mode of administration, researchers wanted to evaluate the proper use of PPIs during admission and discharge. Also, the direct expenses related to improper PPI usage were computed. The appropriateness of PPIs administered in accordance with clinical recommendations was assessed in the medical records of subjects (>18 years of age), hospitalized for >48 hours, and who received PPIs IV or orally throughout their stay. Notably, 80.2% of the 262 patients had a suitable indication for therapy (12.6%) or prophylaxis (67.6%). Pantoprazole IV was prescribed to 230 individuals in total. As found, 122/182 (67%) got IV PPI instead of oral PPI without a suitable indication, whereas 182 (79.1%) had an adequate indication.

The right indication, dosage, and mode of administration were used in 28 (87.5%) of the 32 subjects who got 20 mg omeprazole orally, however, there was an improper frequency in 16/28 (57.1%) of the individuals. As found, 32.5% of subjects were given unnecessary PPI medications after they were discharged. Inappropriate PPI indications and mode of administration resulted in a $1518 total direct cost for 188 patients over six months.

The majority of patients got a PPI for a suitable indication and at the proper dose. The biggest expenditures were nonetheless associated with improper IV pantoprazole administration, which highlighted the need to appropriately prescribe IV drugs. The appropriateness of PPI prescription will be improved, problems will be avoided, and healthcare costs will be decreased by adherence to clinical standards like those of the American College of Gastroenterology (ACG).