The use of a single prophylactic dose of intravenous ibuprofen elicits a reduction in pain severity during the first 24 hours post-surgery, according to a systematic review and meta-analysis. The purpose of this study was to assess the impact of Ibuprofen on post-anesthesia pain.

Databases such as SID, Mag Iran, Web of Science, Cochrane Center for Controlled Trials, Embase, MEDLINE, Scopus, and PubMed were searched using the keywords Ibuprofen, intravenous, postsurgical pain, analgesia, opioid, and analgesia under patient control.

Prophylactic Ibuprofen treatment was shown to considerably lessen pain intensity at 12 hours (Mean Difference, MD=-1.64 [-2.56, -0.72]) and 24 hours (MD = -0.58 [-0.18, -0.99]) after surgery. During the first 24 hours following surgery, a single preventive dose of Ibuprofen reduces the severity of pain; however, its benefits reduce over time.