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Combining the Shugan Hewei formula with Rabeprazole remarkably improves symptom relief in patients with refractory gastroesophageal reflux disease.
Refractory gastroesophageal reflux disease (rGERD) can be challenging to treat. This study by Xiulian Zhang and other researchers investigated its treatment and found evidence of the effectiveness of the Chinese herbal medication Shugan Hewei formula (SHF) alongside Rabeprazole. In this randomized controlled trial, 264 participants were split into two groups: one receiving SHF granules (20 mg) with Rabeprazole (10 mg) and the other receiving placebo SHF granules with Rabeprazole (20 mg) for 8 weeks, followed by 2 weeks of follow-up.
The treatment group illustrated greater overall clinical symptom efficacy and lower total symptom scores when compared to the control group. Additionally, the treatment group outperformed the control group in decreasing major rGERD symptom scores, including heartburn, retrosternal pain, regurgitation, belching, and acid regurgitation. Both the treatment (Z = 8.169) and control groups (Z = 9.800) markedly reduced the degree of esophageal inflammation, showing comparable efficiency (Table 1).
The 36-Item Short Form Survey (SF-36) results indicated that combination therapy prominently enhanced role limitations due to physical health, psychiatric mental health, vitality, general health, and overall somato-physical health. Thus, SHF treatment combined with Rabeprazole is associated with substantial improvements in the therapeutic efficacy for rGERD, offering new options and insights for integrating Traditional Chinese medicine with western medicine for rGERD management.
European Journal of Medical Research
Efficacy of Shugan Hewei formula combined with rabeprazole in refractory gastroesophageal reflux disease: randomized, double-blind, placebo-controlled trial
Xiulian Zhang et al.
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