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Immunosuppression triggered by COVID-19 concomitant with its therapy via corticosteroids and comorbidities of the patients make fungal infections more susceptible.
According to a trial, severe COVID-19 disease is linked to higher levels of the tumour necrosis factor-alpha (TNF-α), interleukin (IL)-1, IL-6, and pro-inflammatory cytokines as well as reduced expression of CD4-interferon-gamma, CD8 and CD4 T cells, all of which raises vulnerability to fungal infections. Researchers aimed to investigate the progression of fungal infections linked to respiratory illnesses brought on by COVID-19.
Considering the significance of the coronavirus infection in connection to co-infections caused by various fungal microorganisms, the features of SARS-CoV-2 and the primary fungal species that are impacting people receiving treatment for severe COVID-19 were identified. Eighty articles from the scientific literature were chosen, with the majority of subjects with severe COVID-19 and concomitant conditions like obesity, oncological disorders, severe liver disease, renal illness, hypertension, and diabetes.
The cases reported by researchers in their series, which demonstrate the overlap of fungal co-infection through compromised immune status brought on by the dysregulation of the microbiota, utilization of therapeutic drugs, patient age, and the severity of the severe inflammation due to COVID-19 are represented by these data rather than the total number of records of the disease in the world.
Fungal infections are more susceptible due to immunosuppression elicited by SARS-CoV-2 infection, its treatment with corticosteroid therapy, and the comorbidities of the people. As a result, they interfere with the COVID-19 treatment and course of the case, making it crucial to recognize secondary infections for treatment and reconstruct the clinical picture as accurately as possible.
Advances in Microbiology
Challenges of the Global COVID-19 Pandemic and Invasive Fungal Pathogens in SARS-COV-2 Associations: A Dangerous Relationship
Alessandra Gomes Mariscal et al.
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