Topical
application of tacrolimus for the short term can be effective in patients with
symptomatic oral lichen planus (OLP) who are resilient to other systemic and
topical treatment regimes. This meta-analysis by Zhangci Su et al. assessed the
safety and efficacy of tacrolimus treatment for OLP patients.
Database
search included exploring the randomized controlled trials on PubMed,
ClinicalTrials.gov, Embase, the Cochrane Library, and Web of Science published
till December 2020 with no constraints on language or date of publication. Risk
of bias for these trials was evaluated via Cochrane Collaboration tool. Nine
clinical trials examining the efficacy of tacrolimus were considered.
The
clinical resolution and relapse between tacrolimus and corticosteroids did not
vary significantly. But, tacrolimus may be more likely to lead to minor adverse
events. The clinical resolution of symptoms did not considerably vary between
tacrolimus and clobetasol propionate, and between tacrolimus and triamcinolone
acetonide, whereas tacrolimus was most probably linked to adverse effects
compared to triamcinolone acetonide and clobetasol propionate.
Evidence for the real impact of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on preterm birth is
unclear, as available series report composite pregnancy outcomes and/or do not
stratify patients according to disease severity. The purpose of the research
was to determine the real impact of asymptomatic/mild SARS-CoV-2 infection on
preterm birth not due to maternal respiratory failure. This case-control study
involved women admitted to Sant Anna Hospital, Turin, for delivery between 20
September 2020 and 9 January 2021. The cumulative incidence of Coronavirus
disease-19 was compared between preterm birth (case group, n = 102) and
full-term delivery (control group, n = 127). Only women with spontaneous or
medically-indicated preterm birth because of placental vascular malperfusion
(pregnancy-related hypertension and its complications) were included. Current
or past SARS-CoV-2 infection was determined by nasopharyngeal swab testing and
detection of IgM/IgG antibodies in blood samples. A significant difference in
the cumulative incidence of Coronavirus disease-19 between the case (21/102,
20.5%) and the control group (32/127, 25.1%) (P= 0.50) was not observed,
although the case group was burdened by a higher prevalence of three known risk
factors (body mass index > 24.9, asthma, chronic hypertension) for severe
Coronavirus disease-19. Logistic regression analysis showed that
asymptomatic/mild SARS-CoV-2 infection was not an independent predictor of
spontaneous and medically-indicated preterm birth due to pregnancy-related
hypertension and its complications (0.77; 95% confidence interval, 0.41-1.43).
Pregnant patients without comorbidities need to be reassured that
asymptomatic/mild SARS-CoV-2 infection does not increase the risk of preterm
delivery. Preterm birth and severe Coronavirus disease-19 share common risk
factors (i.e., body mass index > 24.9, asthma, chronic hypertension), which
may explain the high rate of indicated preterm birth due to maternal conditions
reported in the literature.
Evidence for the real impact of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on preterm birth is
unclear, as available series report composite pregnancy outcomes and/or do not
stratify patients according to disease severity. The purpose of the research
was to determine the real impact of asymptomatic/mild SARS-CoV-2 infection on
preterm birth not due to maternal respiratory failure. This case-control study
involved women admitted to Sant Anna Hospital, Turin, for delivery between 20
September 2020 and 9 January 2021. The cumulative incidence of Coronavirus
disease-19 was compared between preterm birth (case group, n = 102) and
full-term delivery (control group, n = 127). Only women with spontaneous or
medically-indicated preterm birth because of placental vascular malperfusion
(pregnancy-related hypertension and its complications) were included. Current
or past SARS-CoV-2 infection was determined by nasopharyngeal swab testing and
detection of IgM/IgG antibodies in blood samples. A significant difference in
the cumulative incidence of Coronavirus disease-19 between the case (21/102,
20.5%) and the control group (32/127, 25.1%) (P= 0.50) was not observed,
although the case group was burdened by a higher prevalence of three known risk
factors (body mass index > 24.9, asthma, chronic hypertension) for severe
Coronavirus disease-19. Logistic regression analysis showed that
asymptomatic/mild SARS-CoV-2 infection was not an independent predictor of
spontaneous and medically-indicated preterm birth due to pregnancy-related
hypertension and its complications (0.77; 95% confidence interval, 0.41-1.43).
Pregnant patients without comorbidities need to be reassured that
asymptomatic/mild SARS-CoV-2 infection does not increase the risk of preterm
delivery. Preterm birth and severe Coronavirus disease-19 share common risk
factors (i.e., body mass index > 24.9, asthma, chronic hypertension), which
may explain the high rate of indicated preterm birth due to maternal conditions
reported in the literature.
Evidence for the real impact of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on preterm birth is
unclear, as available series report composite pregnancy outcomes and/or do not
stratify patients according to disease severity. The purpose of the research
was to determine the real impact of asymptomatic/mild SARS-CoV-2 infection on
preterm birth not due to maternal respiratory failure. This case-control study
involved women admitted to Sant Anna Hospital, Turin, for delivery between 20
September 2020 and 9 January 2021. The cumulative incidence of Coronavirus
disease-19 was compared between preterm birth (case group, n = 102) and
full-term delivery (control group, n = 127). Only women with spontaneous or
medically-indicated preterm birth because of placental vascular malperfusion
(pregnancy-related hypertension and its complications) were included. Current
or past SARS-CoV-2 infection was determined by nasopharyngeal swab testing and
detection of IgM/IgG antibodies in blood samples. A significant difference in
the cumulative incidence of Coronavirus disease-19 between the case (21/102,
20.5%) and the control group (32/127, 25.1%) (P= 0.50) was not observed,
although the case group was burdened by a higher prevalence of three known risk
factors (body mass index > 24.9, asthma, chronic hypertension) for severe
Coronavirus disease-19. Logistic regression analysis showed that
asymptomatic/mild SARS-CoV-2 infection was not an independent predictor of
spontaneous and medically-indicated preterm birth due to pregnancy-related
hypertension and its complications (0.77; 95% confidence interval, 0.41-1.43).
Pregnant patients without comorbidities need to be reassured that
asymptomatic/mild SARS-CoV-2 infection does not increase the risk of preterm
delivery. Preterm birth and severe Coronavirus disease-19 share common risk
factors (i.e., body mass index > 24.9, asthma, chronic hypertension), which
may explain the high rate of indicated preterm birth due to maternal conditions
reported in the literature.
Evidence for the real impact of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on preterm birth is
unclear, as available series report composite pregnancy outcomes and/or do not
stratify patients according to disease severity. The purpose of the research
was to determine the real impact of asymptomatic/mild SARS-CoV-2 infection on
preterm birth not due to maternal respiratory failure. This case-control study
involved women admitted to Sant Anna Hospital, Turin, for delivery between 20
September 2020 and 9 January 2021. The cumulative incidence of Coronavirus
disease-19 was compared between preterm birth (case group, n = 102) and
full-term delivery (control group, n = 127). Only women with spontaneous or
medically-indicated preterm birth because of placental vascular malperfusion
(pregnancy-related hypertension and its complications) were included. Current
or past SARS-CoV-2 infection was determined by nasopharyngeal swab testing and
detection of IgM/IgG antibodies in blood samples. A significant difference in
the cumulative incidence of Coronavirus disease-19 between the case (21/102,
20.5%) and the control group (32/127, 25.1%) (P= 0.50) was not observed,
although the case group was burdened by a higher prevalence of three known risk
factors (body mass index > 24.9, asthma, chronic hypertension) for severe
Coronavirus disease-19. Logistic regression analysis showed that
asymptomatic/mild SARS-CoV-2 infection was not an independent predictor of
spontaneous and medically-indicated preterm birth due to pregnancy-related
hypertension and its complications (0.77; 95% confidence interval, 0.41-1.43).
Pregnant patients without comorbidities need to be reassured that
asymptomatic/mild SARS-CoV-2 infection does not increase the risk of preterm
delivery. Preterm birth and severe Coronavirus disease-19 share common risk
factors (i.e., body mass index > 24.9, asthma, chronic hypertension), which
may explain the high rate of indicated preterm birth due to maternal conditions
reported in the literature.
Evidence for the real impact of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on preterm birth is
unclear, as available series report composite pregnancy outcomes and/or do not
stratify patients according to disease severity. The purpose of the research
was to determine the real impact of asymptomatic/mild SARS-CoV-2 infection on
preterm birth not due to maternal respiratory failure. This case-control study
involved women admitted to Sant Anna Hospital, Turin, for delivery between 20
September 2020 and 9 January 2021. The cumulative incidence of Coronavirus
disease-19 was compared between preterm birth (case group, n = 102) and
full-term delivery (control group, n = 127). Only women with spontaneous or
medically-indicated preterm birth because of placental vascular malperfusion
(pregnancy-related hypertension and its complications) were included. Current
or past SARS-CoV-2 infection was determined by nasopharyngeal swab testing and
detection of IgM/IgG antibodies in blood samples. A significant difference in
the cumulative incidence of Coronavirus disease-19 between the case (21/102,
20.5%) and the control group (32/127, 25.1%) (P= 0.50) was not observed,
although the case group was burdened by a higher prevalence of three known risk
factors (body mass index > 24.9, asthma, chronic hypertension) for severe
Coronavirus disease-19. Logistic regression analysis showed that
asymptomatic/mild SARS-CoV-2 infection was not an independent predictor of
spontaneous and medically-indicated preterm birth due to pregnancy-related
hypertension and its complications (0.77; 95% confidence interval, 0.41-1.43).
Pregnant patients without comorbidities need to be reassured that
asymptomatic/mild SARS-CoV-2 infection does not increase the risk of preterm
delivery. Preterm birth and severe Coronavirus disease-19 share common risk
factors (i.e., body mass index > 24.9, asthma, chronic hypertension), which
may explain the high rate of indicated preterm birth due to maternal conditions
reported in the literature.
Evidence for the real impact of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on preterm birth is
unclear, as available series report composite pregnancy outcomes and/or do not
stratify patients according to disease severity. The purpose of the research
was to determine the real impact of asymptomatic/mild SARS-CoV-2 infection on
preterm birth not due to maternal respiratory failure. This case-control study
involved women admitted to Sant Anna Hospital, Turin, for delivery between 20
September 2020 and 9 January 2021. The cumulative incidence of Coronavirus
disease-19 was compared between preterm birth (case group, n = 102) and
full-term delivery (control group, n = 127). Only women with spontaneous or
medically-indicated preterm birth because of placental vascular malperfusion
(pregnancy-related hypertension and its complications) were included. Current
or past SARS-CoV-2 infection was determined by nasopharyngeal swab testing and
detection of IgM/IgG antibodies in blood samples. A significant difference in
the cumulative incidence of Coronavirus disease-19 between the case (21/102,
20.5%) and the control group (32/127, 25.1%) (P= 0.50) was not observed,
although the case group was burdened by a higher prevalence of three known risk
factors (body mass index > 24.9, asthma, chronic hypertension) for severe
Coronavirus disease-19. Logistic regression analysis showed that
asymptomatic/mild SARS-CoV-2 infection was not an independent predictor of
spontaneous and medically-indicated preterm birth due to pregnancy-related
hypertension and its complications (0.77; 95% confidence interval, 0.41-1.43).
Pregnant patients without comorbidities need to be reassured that
asymptomatic/mild SARS-CoV-2 infection does not increase the risk of preterm
delivery. Preterm birth and severe Coronavirus disease-19 share common risk
factors (i.e., body mass index > 24.9, asthma, chronic hypertension), which
may explain the high rate of indicated preterm birth due to maternal conditions
reported in the literature.
No
significant difference in pain relief between tacrolimus and clobetasol was
determined. Also, adverse events did not considerably vary amongst tacrolimus
and pimecrolimus. Thus, short-term
application of tacrolimus can be an effective therapeutic regimen for the
management of OLP people.
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