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Targeted strategies can help to break vaccination barriers, especially in underserved communities, boosting global health outcomes.
Despite the well-established ability of vaccines to drastically reduce mortality and morbidity from preventable diseases, vaccination rates around the world still fall short of the desired targets. Sicong Liu et al. examined the data from 88 randomized controlled trials involving over 1.6 million participants across 17 countries with varying levels of development (Human Development Index ranging from 0.485 to 0.955) in this in-depth meta-analysis.
The main aim was to study the effectiveness of 7 different strategies designed to improve vaccination uptake, comprising increasing vaccine accessibility, sending reminders, offering incentives, providing educational information, correcting misinformation, fostering both active and passive motivation, and teaching behavioral skills.
People in the intervention groups had 1.5 times higher odds of receiving vaccinations compared to control groups, with a 95% confidence interval of 1.27 to 1.77. Among the various strategies, offering incentives and improving access to vaccines emerged as the most effective approaches, with access-related interventions showing especially strong results in lower-income countries with more limited healthcare infrastructure.
Nature Human Behaviour
A systematic review and meta-analysis of strategies to promote vaccination uptake
Sicong Liu et al.
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