Within the constraints, this regenerative injection therapy using dextrose leads to a considerable reductions in pain and mouth opening, two of the most prevalent symptoms of TMJ hypermobility. To evaluate these outcomes, a systematic review and meta-analysis was conducted that involves the data of controlled clinical trials (CCTs) and Randomised clinical trials (RCTs), extracted from CENTRAL, scopus, pubmed and google scholar databases.

In total three RCTs were included for the analysis, exhibited a considerable difference in Maximal mouth opening (MMO) on pooling of data and reduction in pain as compared to the placebo. However, the inter-group difference between the groups regarding pain was negligible. Finally, the difference between the dextrose and placebo regarding the frequency of sulbluxation/dislocation was negligible. Findings in relation to decline episodes of  sulbluxation/dislocation cannot be pulled at this point. Further assessments of more high quality RCTs with homogenous prolotherapy and larger sample size are required.