According to a recent study published in Allergy, Asthma and Clinical Immunology, the use of adjuvant therapy with a combination probiotic formula comprising of Lactobacillus and Bifidobacteria  was safe and effective for chronic urticaria treatment in school going children at 4 weeks. 

To understand the efficacy of probiotic formula as adjuvant therapy, Xiao-Dong Bi and researchers enrolled 206 children diagnosed with chronic urticaria. These children were divided into: Treatment group in which 104 patients were given desloratadine dry suspension and probiotic formula or; Placebo group in which 102 patients were given only the dry suspension.

As found, the clinical symptom scores did not vary considerably at the follow-up of 1 and 2 weeks. However, by the end of 4 weeks, the size of wheal and attack frequency significantly decreased in the treatment group. A variation in the overall response rate (significant improvement and complete response) amongst treatment group (80.8%) and placebo group (62.5%) was observed.