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Aminophylline 2 or 4 mg/kg use before pelvic-abdominal surgeries
can be used to promote recovery.
According to a study in BMC Anesthesiology, the use of aminophylline (nonselective adenosine receptor antagonist) prior to pelvic-abdominal
surgeries under general anesthesia can enhance recovery without risk of
cardiovascular issues.
The study authors compared the effects of various doses of
aminophylline on the recovery when used prior to surgery.
Overall, 45 patients planned for
pelvic-abdominal surgeries were allotted into 3 groups:
Patients’ demographic data, ASA physical status, anaesthesia
and surgery duration, heart rate, mean arterial blood pressure (BP), propofol
and fentanyl dose, time till bispectral index
(BIS) (48 ± 2) after anaesthesia and to reach 80 following the stoppage
of sevoflurane anaesthesia, extubation time and to discharge from the
post-anaesthesia care unit (PACU), and adverse effects of aminophylline were
noted.
As found, time till BIS of 48 ± 2 was considerably lesser for group C (70.67 ± 22.50) as compared to group A2 (106.67 ± 34.77 s for A2 group). Time to reach BIS of 80, ROC and extubation time was considerably longer for the group C than group A1 andA2, refer the table and figure below:
Future studies are suggested in various
surgeries to authenticate the capability of aminophylline to boost recovery and
quick discharge from the PACU, study authors noted.
BMC Anesthesiology
The effect of preoperative aminophylline on the recovery profile after major pelvic-abdominal surgeries: a randomized controlled double-blinded study
Samaa A. Kasim et al.
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