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Exposure to parabens is linked with a raised
risk of atopic dermatitis in children.
According to the findings of a study
published in Allergy, prenatal parabens (ethylparaben and n‐butylparaben)
exposure may elevate children's susceptibility for persistent atopic dermatitis
with the onset of disease at a very early age. Researchers undertook this study to determine if prenatal paraben
exposure was linked with a raised risk of
atopic dermatitis in children.
This study was based on a sub cohort of 261 mother-children pairs of the prospective German mother-child cohort LINA. At gestational week 34, about eight paraben species were quantified in the maternal urine. Childhood atopic dermatitis was divided into 4 distinct phenotypes on the basis of the parental report of clinician-diagnosed dermatitis from age one to eight years, and onset and persistence of disease.
It was observed that a total of 12 (4.6%) and
32 (12.3%) children until age two were classified as suffering from very
early‐onset atopic dermatitis with or
without remission. Notably, 31 children
(11.9%) were classified as early-onset (after the age of two), and 8 children
(3.1%) as childhood-onset atopic dermatitis
(after the age of six).
Exposure
to parabens like n-butylparaben and
ethylparaben was found to be linked with an elevated risk for developing very
early-onset atopic dermatitis without any remission. In children without a
history of maternal atopic dermatitis, the influence of both parabens was found
to be predominant and independent of
children's gender.
The link was specifically prominent in children without a history of maternal atopic dermatitis. This demonstrated that children without a genetic predisposition are highly vulnerable to exposure to paraben. Thus, prenatal parabens exposure can escalate the risk of atopic dermatitis.
Allergy
Prenatal paraben exposure and atopic dermatitis‐related outcomes among children
Loreen Thürmann et al.
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