According to a randomized controlled trial, posterior nasal neurectomy (PNN) improves the quality of life and can assist in the effective management of chronic rhinosinusitis with nasal polyposis (CRSwNP) symptoms. Yash Mittal et al. sought to assess PNN effectiveness for CRSwNP management.

Overall, 46 CRSwNP patients (23 patients in the study and 23 in the control group) were incorporated. PNN and endoscopic sinus surgery (ESS) were performed on patients in the trial group, whereas ESS was performed on patients in the control group. At 1, 4, 12, and 24 weeks following the procedure, the improvement in symptoms and quality of life was evaluated.

A profound difference was discovered between the postoperative and preoperative scores (Lund - Kennedy [LK], Rhinosinusitis Disability Index [RSDI], and 22-item Sinonasal Outcome Test [SNOT-22] Score) on intragroup analysis. For the SNOT-22 and RSDI scores at 1 week and 4 weeks, a significant difference was seen when the improvement of outcome scores between both  groups was examined.

Between both groups, no discernible difference was seen in the duration of complications/surgery. PNN may help in the symptomatic control of CRSwNP and improvement in the quality of life of individuals. For a better understanding of the PNN's effectiveness in patients with CRSwNP, a bigger sample size with long-term follow-up may be necessary.