A double-blind randomized study depicted that better improvement in postoperative inflammatory morbidities was achieved by platelet-rich fibrin (PRF) compared to platelet-rich plasma (PRP) in people undergoing impacted lower third molar surgery. O Osagie et al. aimed to compare the bioactive impact of PRF and PRP on postoperative pain, trismus, and swelling following dental surgery.

Overall, 50 subjects were included and segregated into PRP and PRF groups. On day 1, 3, and 7, the preoperative and postsurgery swelling,  pain, and degree of mouth opening were estimated. To assess the impact of the intervention, treatment with time interaction, and time-point evaluation within the group, linear mixed model analysis was used.

Interaction estimates depicted a clinically meaningful decrease in pain with PRF. There was a reduction in facial swelling and trismus (on the basis of time-point evaluation) within PRF and PRP groups. Regarding swelling and trismus, no statistically profound inter-group differences were witnessed. Age was found to be a remarkable predictor of trismus in both groups. Thus, platelet concentrates positively regulate the post-inflammatory sequelae of dental surgery.