According to a prospective study published in the American Journal of Otolaryngology, the use of platelet-rich fibrin (PRF) lead to improved outcomes concerning tissue healing, adhesion formation, infection, bleeding, granulation, and frontal ostium stenosis following the Endoscopic sinus surgery (ESS).

ESS is a well-recognized procedure for nasal polyps and refractory chronic rhinosinusitis. Good wound healing and less adhesion formation is pivotal for preventing revision surgery. PRF has been known promote tissue healing in dental implant and plastic surgery.

Hüseyin Sari et al. recruited 50 patients who underwent ESS for nasal polyposis diagnosis. In one nasal cavity, the middle meatus was packed with PRF and reinforced with nasal dressing, whereas in the other nasal cavity middle meatus had only nasal dressing. After the surgery, the patients were followed up at 1st, 2nd, 3rd, 4th, 8th, and 12^th week. The occurrence of adhesion, crusting, bleeding, frontal ostium stenosis, granulation, and infection were determined and if available, the grading of these complications was done via a questionnaire.

As found, the above mentioned complications were less common in the PRF group, and there was a statistically significant difference amongst the groups.