Evident from the reports of a recently published meta-analysis, intra‐articular infiltrations of ozone provides short-term efficacy to alleviate pain associated with knee osteoarthritis.

A total of eight studies comprised 355 patients, and 363 controls were identified by searching SCIELO, ISCO3, DIALNET, PUBMED, and MEDIGRAPHIC databases. The randomized controlled trials that involved intra‐articular or peri‐articular infiltrations with ozone efficacy to manage knee osteoarthritis in humans were selected. Standardized mean difference and 95% CI was used to express the outcomes, and meta-analysis was performed.

Ozone treatment has found to have therapeutic effects when compared to placebo or other non-invasive methods. However, as compared to the platelet‐rich plasma or hyaluronic acid, ozone treatment exhibited no significant improvement in therapeutic effects. Although, ozone treatment had short-term pain relief benefits that last 3‐6 months. More investigations are required to understand the treatment's efficacy.