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Nonsteroidal anti-inflammatory drug (NSAIDs) can be safely
prescribed after total joint arthroplasty as it is not associated with
gastrointestinal bleeding.
As per a retrospective study published in “The Journal of Arthroplasty”, NSAIDs were not found to be linked with gastrointestinal bleeding and can be safely prescribed for a majority of patients after total joint arthroplasty. Researchers undertook this assessment to determine whether extended NSAIDs after joint arthroplasty can raise the gastrointestinal bleeding risk.
Overall, 28,794 adults who underwent joint arthroplasty were included. The episodes of gastrointestinal bleeding within 90 days of postsurgery were prospectively recognized. Using electronic questionnaires, the postsurgery medications were directly reported by patients. With the aid of binary logistic regression, the primary assessment was carried out.
It was noted that 74 (0.26%) episodes of gastrointestinal bleeding took place within 90 days (median 8 days) after surgery. Of 5,086 participants with complete data incorporated in the primary assessment, 59.6% had used NSAIDs with a median duration of two weeks (interquartile range, 0–6 weeks). Individuals having gastrointestinal bleeding were considerably older (71.3 years vs. 67.0 years), needed longer hospitalizations (2.1 vs. 1.5 days), and had peptic ulcer history (10.8% vs. 0.9%).
But, no positive link between gastrointestinal bleeding and
NSAID usage was noted. The odds of gastrointestinal bleeding were found to be
minimized in individuals taking NSAIDs. Notably, gastrointestinal bleeding was
linked with antiplatelets, anticoagulants, and to a lesser extent aspirin. The
highest odds of gastrointestinal bleeding took place in individuals having
peptic ulcers and individuals receiving anticoagulation medications and
antiplatelets. Bilateral surgery and increasing age were also linked with
gastrointestinal bleeding, concluded by the authors.
The Journal of Arthroplasty
Risk of Gastrointestinal Bleeding with Extended Use of Nonsteroidal Anti-inflammatory Drug Analgesia After Joint Arthroplasty
Andrew N. Flieschman et al.
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