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The use of proton pump inhibitor-amoxicillin dual therapy 4
times per day is beneficial to treat Helicobacter pylori (H.
pylori) infection.
According to a recent systematic review and meta-analysis of randomized trials comparing the proton pump inhibitor (PPI)-amoxicillin dual therapy with other treatments, it was found that the dual therapy administered 4 times per day had better safety and efficacy in the eradication of H. pylori as compared to the existing first-line, recommended regimens.
This review was performed by Cailing Li and investigators to clarify if the dual therapy is superior to the guidelines recommended regimens. The randomized trials comparing the PPI-amoxicillin dual therapy with other treatments were subjected to meta-analysis to assess the eradication rate, adverse drug reactions, and compliance with the help of a random-effects model.
As shown, 4 times daily use of dual therapy had a higher eradication rate compared to other treatment routines, as shown below (Table 1):
Also, in the first-line therapy, a higher eradication rate of dual therapy as per intention-to-treat and per-protocol analysis (not significant) compared to other regimens was found (Table 2):
Salvage treatment had no significant difference. Dual
therapy was regarded safe than other therapies, although there was no variation
in compliance.
Helicobacter
PPI-amoxicillin dual therapy four times daily is superior to guidelines recommended regimens in the Helicobacter pylori eradication therapy within Asia: A systematic review and meta-analysis
Cailing Li et al.
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