A recent study conducted by Narges Heshmatifar et al. depicted that skin traction, pressure, and rapid muscle release (TPR) could be used as a substitute to the Z-track method for reducing the intramuscular (IM) injection pain. In this study, a total of 63 patients were enrolled in the triple-blind randomized clinical trial who were injected with two 5-cc Methocarbamol IM injection, which was delivered via two techniques in two different muscles to compare the results efficiently. In the innovative TPR technique, the needle was inserted at a 90° angle after applying skin traction and imposing deep pressure on the muscle so that the skin and muscle release rapidly towards the needle. In contrast, no muscle release applied in the case of the Z-track method. Visual analogue scale (VAS) was used to identify the intensity of pain, and the findings showed pain intensity in TPR and Z-track methods 1.68 ± 1.20 and 3.76 ± 1.42, respectively, which is a statistically significant difference. These results prove the better pain reduction at the IM site with the TPR method than the Z-track method. Thus, the TPR method could be an efficient substitute for the Z-track method.