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In patients with long COVID, significant brain abnormalities are present.
As per the findings of a study being presented at the annual meeting of Radiological Society of North America (RSNA), researchers have discovered brain anomalies using a particular type of magnetic resonance imaging (MRI) in individuals up to six months after they recovered from coronavirus disease. The affected brain regions were linked with insomnia, anxiety, depression, headache, cognitive problems, and fatigue. As per the U.S. Centers for Disease Control and Prevention, coronavirus disease will have long-term impacts on about 1 in 5 adults.
Few neurological signs of long COVID encompass headache, cognitive difficulties, sleep issues, lightheadedness, pins and needles sensations, alteration in smell or taste, attentional difficulties, and anxious or depressive symptoms. Even in asymptomatic patients, the lungs, heart, or other organs might alter as a result of coronavirus infection, according to research. Investigations on the long-term effects of COVID-19 have started to emerge as more people contract the illness and recover from it.
For examining COVID-19's effects on the brain, susceptibility-weighted imaging was utilized.
Magnetic susceptibility indicates how much a substance, such as calcium, iron, or blood, will magnetize when a magnetic field is applied. Stroke, brain tumors, microbleeds, and vascular deformities are just a few of the neurologic disorders that are discovered and monitored using this ability. In spite of several case reports indicating anomalies, group-level investigations on COVID-19 alterations in the brain's magnetic susceptibility have not yet been prioritized.
The current research focused on this novel element of COVID-19's neurological consequences and documented severe abnormalities in COVID survivors. Susceptibility-weighted MRI data of 46 COVID-recovered people and 30 healthy controls were examined by investigators. Within 6 months of recovery, imaging was performed. Among subjects with long COVID, the most commonly encountered symptoms were difficulty sleeping, memory impairment, fatigue, and lack of focus.
Alterations in the brain region's susceptibility levels may be a sign of local compositional alterations. Lower susceptibilities might be elicited by anomalies like calcification or a paucity of iron-containing paramagnetic molecules, whereas susceptibilities may represent the existence of abnormal amount of paramagnetic compounds. The MRI findings demonstrated that subjects who recovered from coronavirus infection had frontal lobe and brain stem susceptibility values that were remarkably higher when compared to the healthy controls. In the white matter, the frontal lobe clusters considerably displayed variations. These parts of the brain are associated with inability to sleep, anxiety, depression, headaches, cognitive issues, and fatigue.
The frontal lobe clusters are made up of adjacent white matter areas, sections of the left orbital-inferior frontal gyrus, which is pivotal for language understanding, and the right orbital-inferior frontal gyrus, which is linked to a variety of cognitive processes, encompassing attention, motor suppression, and imagery, along with social cognitive procedures.
Investigators noted a meaningful difference in right ventral diencephalon area of the brain stem that is implicated in a wide array of vital biological processes, like transmitting motor and sensory information to cerebral cortex, coordinating hormones release with the endocrine system, and monitoring the sleep-wake cycle (circadian cycles). This study suggested that the coronavirus may have substantial long-term side effects, even months after an infection has been treated.
The current findings of the study are from a very small temporal window. Over a few years, the longitudinal time points would disclose whether there has been any long-term modification. To find out if these brain anomalies last for a longer period of time, the researchers are performing a longitudinal study on the same patient group.
RSNA Press Release
MRI Reveals Significant Brain Abnormalities Post-COVID
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