According
to a population-based study published in PLoS One, 1 in 4 women
continued triptan treatment throughout pregnancy, and the extended triptan use
was relatively low. Also, women usually stopped the use of triptan during and
in the year following the pregnancy. This study was performed to understand the
association of migraine pharmacotherapy prior to, throughout, and following
pregnancy in females with triptan use.
This
study incorporated 22,940 pregnancies in a total of 19,669 females with at
least 1 filled triptan prescript, a substitution for migraine, in the year
prior to pregnancy or throughout pregnancy. They were divided into four groups,
namely: continuers (20% of women), discontinuers (54.1% of women), initiators
(8% of women), and re-initiators after childbirth (17.6% of women). The patient
demographics and prescription fill for other medicines (anti-nauseants,
analgesics, and preventive therapies) were assessed, along with the triptan
utilization parameters.
Evidence for the real impact of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on preterm birth is
unclear, as available series report composite pregnancy outcomes and/or do not
stratify patients according to disease severity. The purpose of the research
was to determine the real impact of asymptomatic/mild SARS-CoV-2 infection on
preterm birth not due to maternal respiratory failure. This case-control study
involved women admitted to Sant Anna Hospital, Turin, for delivery between 20
September 2020 and 9 January 2021. The cumulative incidence of Coronavirus
disease-19 was compared between preterm birth (case group, n = 102) and
full-term delivery (control group, n = 127). Only women with spontaneous or
medically-indicated preterm birth because of placental vascular malperfusion
(pregnancy-related hypertension and its complications) were included. Current
or past SARS-CoV-2 infection was determined by nasopharyngeal swab testing and
detection of IgM/IgG antibodies in blood samples. A significant difference in
the cumulative incidence of Coronavirus disease-19 between the case (21/102,
20.5%) and the control group (32/127, 25.1%) (P= 0.50) was not observed,
although the case group was burdened by a higher prevalence of three known risk
factors (body mass index > 24.9, asthma, chronic hypertension) for severe
Coronavirus disease-19. Logistic regression analysis showed that
asymptomatic/mild SARS-CoV-2 infection was not an independent predictor of
spontaneous and medically-indicated preterm birth due to pregnancy-related
hypertension and its complications (0.77; 95% confidence interval, 0.41-1.43).
Pregnant patients without comorbidities need to be reassured that
asymptomatic/mild SARS-CoV-2 infection does not increase the risk of preterm
delivery. Preterm birth and severe Coronavirus disease-19 share common risk
factors (i.e., body mass index > 24.9, asthma, chronic hypertension), which
may explain the high rate of indicated preterm birth due to maternal conditions
reported in the literature.
Evidence for the real impact of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on preterm birth is
unclear, as available series report composite pregnancy outcomes and/or do not
stratify patients according to disease severity. The purpose of the research
was to determine the real impact of asymptomatic/mild SARS-CoV-2 infection on
preterm birth not due to maternal respiratory failure. This case-control study
involved women admitted to Sant Anna Hospital, Turin, for delivery between 20
September 2020 and 9 January 2021. The cumulative incidence of Coronavirus
disease-19 was compared between preterm birth (case group, n = 102) and
full-term delivery (control group, n = 127). Only women with spontaneous or
medically-indicated preterm birth because of placental vascular malperfusion
(pregnancy-related hypertension and its complications) were included. Current
or past SARS-CoV-2 infection was determined by nasopharyngeal swab testing and
detection of IgM/IgG antibodies in blood samples. A significant difference in
the cumulative incidence of Coronavirus disease-19 between the case (21/102,
20.5%) and the control group (32/127, 25.1%) (P= 0.50) was not observed,
although the case group was burdened by a higher prevalence of three known risk
factors (body mass index > 24.9, asthma, chronic hypertension) for severe
Coronavirus disease-19. Logistic regression analysis showed that
asymptomatic/mild SARS-CoV-2 infection was not an independent predictor of
spontaneous and medically-indicated preterm birth due to pregnancy-related
hypertension and its complications (0.77; 95% confidence interval, 0.41-1.43).
Pregnant patients without comorbidities need to be reassured that
asymptomatic/mild SARS-CoV-2 infection does not increase the risk of preterm
delivery. Preterm birth and severe Coronavirus disease-19 share common risk
factors (i.e., body mass index > 24.9, asthma, chronic hypertension), which
may explain the high rate of indicated preterm birth due to maternal conditions
reported in the literature.
Evidence for the real impact of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on preterm birth is
unclear, as available series report composite pregnancy outcomes and/or do not
stratify patients according to disease severity. The purpose of the research
was to determine the real impact of asymptomatic/mild SARS-CoV-2 infection on
preterm birth not due to maternal respiratory failure. This case-control study
involved women admitted to Sant Anna Hospital, Turin, for delivery between 20
September 2020 and 9 January 2021. The cumulative incidence of Coronavirus
disease-19 was compared between preterm birth (case group, n = 102) and
full-term delivery (control group, n = 127). Only women with spontaneous or
medically-indicated preterm birth because of placental vascular malperfusion
(pregnancy-related hypertension and its complications) were included. Current
or past SARS-CoV-2 infection was determined by nasopharyngeal swab testing and
detection of IgM/IgG antibodies in blood samples. A significant difference in
the cumulative incidence of Coronavirus disease-19 between the case (21/102,
20.5%) and the control group (32/127, 25.1%) (P= 0.50) was not observed,
although the case group was burdened by a higher prevalence of three known risk
factors (body mass index > 24.9, asthma, chronic hypertension) for severe
Coronavirus disease-19. Logistic regression analysis showed that
asymptomatic/mild SARS-CoV-2 infection was not an independent predictor of
spontaneous and medically-indicated preterm birth due to pregnancy-related
hypertension and its complications (0.77; 95% confidence interval, 0.41-1.43).
Pregnant patients without comorbidities need to be reassured that
asymptomatic/mild SARS-CoV-2 infection does not increase the risk of preterm
delivery. Preterm birth and severe Coronavirus disease-19 share common risk
factors (i.e., body mass index > 24.9, asthma, chronic hypertension), which
may explain the high rate of indicated preterm birth due to maternal conditions
reported in the literature.
Evidence for the real impact of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on preterm birth is
unclear, as available series report composite pregnancy outcomes and/or do not
stratify patients according to disease severity. The purpose of the research
was to determine the real impact of asymptomatic/mild SARS-CoV-2 infection on
preterm birth not due to maternal respiratory failure. This case-control study
involved women admitted to Sant Anna Hospital, Turin, for delivery between 20
September 2020 and 9 January 2021. The cumulative incidence of Coronavirus
disease-19 was compared between preterm birth (case group, n = 102) and
full-term delivery (control group, n = 127). Only women with spontaneous or
medically-indicated preterm birth because of placental vascular malperfusion
(pregnancy-related hypertension and its complications) were included. Current
or past SARS-CoV-2 infection was determined by nasopharyngeal swab testing and
detection of IgM/IgG antibodies in blood samples. A significant difference in
the cumulative incidence of Coronavirus disease-19 between the case (21/102,
20.5%) and the control group (32/127, 25.1%) (P= 0.50) was not observed,
although the case group was burdened by a higher prevalence of three known risk
factors (body mass index > 24.9, asthma, chronic hypertension) for severe
Coronavirus disease-19. Logistic regression analysis showed that
asymptomatic/mild SARS-CoV-2 infection was not an independent predictor of
spontaneous and medically-indicated preterm birth due to pregnancy-related
hypertension and its complications (0.77; 95% confidence interval, 0.41-1.43).
Pregnant patients without comorbidities need to be reassured that
asymptomatic/mild SARS-CoV-2 infection does not increase the risk of preterm
delivery. Preterm birth and severe Coronavirus disease-19 share common risk
factors (i.e., body mass index > 24.9, asthma, chronic hypertension), which
may explain the high rate of indicated preterm birth due to maternal conditions
reported in the literature.
Evidence for the real impact of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on preterm birth is
unclear, as available series report composite pregnancy outcomes and/or do not
stratify patients according to disease severity. The purpose of the research
was to determine the real impact of asymptomatic/mild SARS-CoV-2 infection on
preterm birth not due to maternal respiratory failure. This case-control study
involved women admitted to Sant Anna Hospital, Turin, for delivery between 20
September 2020 and 9 January 2021. The cumulative incidence of Coronavirus
disease-19 was compared between preterm birth (case group, n = 102) and
full-term delivery (control group, n = 127). Only women with spontaneous or
medically-indicated preterm birth because of placental vascular malperfusion
(pregnancy-related hypertension and its complications) were included. Current
or past SARS-CoV-2 infection was determined by nasopharyngeal swab testing and
detection of IgM/IgG antibodies in blood samples. A significant difference in
the cumulative incidence of Coronavirus disease-19 between the case (21/102,
20.5%) and the control group (32/127, 25.1%) (P= 0.50) was not observed,
although the case group was burdened by a higher prevalence of three known risk
factors (body mass index > 24.9, asthma, chronic hypertension) for severe
Coronavirus disease-19. Logistic regression analysis showed that
asymptomatic/mild SARS-CoV-2 infection was not an independent predictor of
spontaneous and medically-indicated preterm birth due to pregnancy-related
hypertension and its complications (0.77; 95% confidence interval, 0.41-1.43).
Pregnant patients without comorbidities need to be reassured that
asymptomatic/mild SARS-CoV-2 infection does not increase the risk of preterm
delivery. Preterm birth and severe Coronavirus disease-19 share common risk
factors (i.e., body mass index > 24.9, asthma, chronic hypertension), which
may explain the high rate of indicated preterm birth due to maternal conditions
reported in the literature.
Evidence for the real impact of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on preterm birth is
unclear, as available series report composite pregnancy outcomes and/or do not
stratify patients according to disease severity. The purpose of the research
was to determine the real impact of asymptomatic/mild SARS-CoV-2 infection on
preterm birth not due to maternal respiratory failure. This case-control study
involved women admitted to Sant Anna Hospital, Turin, for delivery between 20
September 2020 and 9 January 2021. The cumulative incidence of Coronavirus
disease-19 was compared between preterm birth (case group, n = 102) and
full-term delivery (control group, n = 127). Only women with spontaneous or
medically-indicated preterm birth because of placental vascular malperfusion
(pregnancy-related hypertension and its complications) were included. Current
or past SARS-CoV-2 infection was determined by nasopharyngeal swab testing and
detection of IgM/IgG antibodies in blood samples. A significant difference in
the cumulative incidence of Coronavirus disease-19 between the case (21/102,
20.5%) and the control group (32/127, 25.1%) (P= 0.50) was not observed,
although the case group was burdened by a higher prevalence of three known risk
factors (body mass index > 24.9, asthma, chronic hypertension) for severe
Coronavirus disease-19. Logistic regression analysis showed that
asymptomatic/mild SARS-CoV-2 infection was not an independent predictor of
spontaneous and medically-indicated preterm birth due to pregnancy-related
hypertension and its complications (0.77; 95% confidence interval, 0.41-1.43).
Pregnant patients without comorbidities need to be reassured that
asymptomatic/mild SARS-CoV-2 infection does not increase the risk of preterm
delivery. Preterm birth and severe Coronavirus disease-19 share common risk
factors (i.e., body mass index > 24.9, asthma, chronic hypertension), which
may explain the high rate of indicated preterm birth due to maternal conditions
reported in the literature.
In the first
trimester, 6.9% of the continuers had prolonged triptans (≥15 daily drug doses
per month) usage. The highest 10% of triptan continuers and initiators made up
for 41% and 33% of the triptan volume, correspondingly. Comparable
patterns of the acute co-medication during the period of pregnancy was observed
in continuers and initiators. Nevertheless, the use of
preventive medicines was more frequent in continuers prior, throughout, and
following the pregnancy.
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