The results of a systematic review and meta-analysis demonstrated that mindfulness-based interventions can effectively minimize anxiety and depression symptoms, and boost health-associated quality of life in women with infertility. This study sought to explore how mindfulness-based therapies affected the physical and mental health of infertile women.

Studies were incorporated if they involved women who had been given an infertility diagnosis, were older than eighteen years, and the design was a randomized controlled trial of a mindfulness-based intervention program. Data extraction, methodological quality evaluation, and eligibility screening were all carried out independently by two reviewers. The meta-analyses were carried out using RevMan software, version 5.4 (Cochrane Collaboration). It was done in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). A total of 10 articles were finally incorporated.

The results illustrated large, significant effects of mindfulness-based interventions that can effectively minimize depression [standardized mean difference [SMD] = -1.28, 95% CI (-1.95, -0.60)], anxiety [SMD = -0.89, 95% CI (-1.26, -0.51)] symptoms, and improve five domains of health-related quality of life: (1) physical function [mean difference [MD] = 9.47, 95% CI (4.33, 14.61)], (2) vitality [MD = 14.85, 95% CI (4.95, 24.74)], (3) social function [MD = 8.27, 95% CI (3.56, 12.97)], (4) general health [MD = 15.77, 95% CI (7.62, 23.92)], and (5) role-physical [MD = 22.44, 95% CI (14.97, 29.91)] in females having infertility.

Future rigorously designed, high-quality investigation is needed to assess whether mindfulness-based intervention programs can effectively diminish perceived stress and body-mass index.