Categories
Change Password!
Reset Password!
Leukocyte-poor platelet-rich plasma (LP-PRP) injections provide more significant clinical improvement than hyaluronic (HA) injections and NSAIDs in patients with knee osteoarthritis (KOA). However, no effect on cartilage progression is noted.
Extensive research is being undertaken for the betterment of QOL in knee osteoarthritis patients, out of which the results from one randomized controlled trial proved that Leukocyte-poor platelet-rich plasma (LP-PRP) injections exhibit better clinical efficacy as compared to oral NSAIDs or HA injections among patients with knee osteoarthritis.
The incidence of people suffering from knee OA is quite high. Various approaches like intra-articular injections [hyaluronic acid (HA) or platelet-rich plasma (PRP)] or oral Nonsteroidal anti-inflammatory drugs (NSAID) are used to counter this devastating disease.
A 52-week follow-up
study results from all the three treatment approaches PRP and NSAIDs/hyaluronic acid was made to
elucidate radiographic evolution and clinical effectiveness among KOA patients.
A total of 106 patients were selected and categorised as per the Spanish
Rheumatology Society knee osteoarthritis diagnosis criteria. Thirty-Three
patients of each PRP, hyaluronic and NSAID group have completed the trial. The
visual analogue scale (VAS) and Western Ontario McMaster Universities
osteoarthritis index (WOMAC) used to measure outcomes at baseline, 26 and 52
weeks. The MRI and X-ray were used at baseline and 52 weeks. The patients who
received PRP showed 30% rate of response towards a 20% decrease in WOMAC pain
scale and a 24% increase in physical function. The NSAID and HA group also showed
an improvement in WOMAC pain and VAS scores. However, PRP exhibited better
outcomes as compared to other groups (P < 0.05). No influence was seen on
Kellgren–Lawrence or cartilage thickness progression. The findings reflect that
PRP shows better efficacy with no impact on cartilage progression.
J Orthop Traumatol
Clinical and radiographic comparison of a single LP-PRP injection, a single hyaluronic acid injection and daily NSAID administration with a 52-week follow-up: a randomized controlled trial.
David Buendía-López et al.
Comments (0)