According to the findings of a randomized, parallel, double-blind trial, a low dose of Etoricoxib exhibits a pre-emptive analgesic effect, resulting in the decreased use of analgesics following third molar removal in comparison with Aceclofenac - paracetamol combination. The researchers intended to contrast the preemptive analgesic effects of Etoricoxib with a combination of Aceclofenac and Paracetamol in dental surgery.

The study enrolled 100 medically fit participants aged 18 years or above, possessing horizontally impacted teeth, who had refrained from consuming anti-inflammatory medications or analgesics in the preceding week. They were segregated into two groups using a random allocation. Pain evaluations were conducted using the visual analog score (VAS) scale immediately after the surgery, one hour post-surgery, and on the first postoperative day.

Both medications were administered 30 minutes before the surgical procedure. Using Pearson linear correlation, the analysis of the rescue medication was done. A statistically significant distinction existed between both the preemptive analgesia methods (Etoricoxib and Aceclofenac + Paracetamol), with notably lower VAS scores observed in the Etoricoxib group immediately after, at 1 hour, and at 24 hours.

In conclusion, the study's findings underscore the efficacy of administering a low dose of Etoricoxib as a preemptive analgesic strategy. This approach demonstrated a notable reduction in the need for postoperative analgesics following third molar extraction, presenting a favorable alternative to the Aceclofenac-Paracetamol combination.