The continuous administration of long-term medical treatment via Eps soon after conservative surgery (laparoscopic excision) for endometriomas was found to lessen the probability of disease recurrence, a retrospective cohort study in Gynecologic and obstetric investigation mentioned.

Simona Del Forno et al. assessed the efficacy of long-term medical therapy using EPs or progestins in the prevention of endometrioma recurrence in 375 females presented for laparoscopic excision with a follow-up at 6 and 12 months and then annually following the procedure.

The females were women were allocated into 4 groups i.e. cyclic EP users, continuous EP users, progestogen users, and non-users. Their anamnestic and anthropometric features along with clinical and surgical data were noted. The numerical rating score >5 was used for pain assessment. At each gynecological examination, the Endometrioma recurrence at ultrasound (ovarian cyst with standard sonographic characteristics ≥10 mm in mean diameter) was noted.

The patients mainly used EPs (119 cyclic users; 61 continuous users), 95 used progestins, and 100 were non-users. The endometriotic cyst recurrence (mean diameter of 18.7 ± 10.8 mm) was identified in 135 women (36%) and the recurrent cyst-free period was observed as 7.9 years. The first symptom noted after reappearance was dysmenorrhea which affected 162 patients (43.2%). Continuous EP users had a lower risk of relapse, concerning cysts and symptom recurrence, compared to non-users. The rate of reoperation was 16.2%.